IL-18 Serves as a Main Effector of CAF-Derived METTL3 Against Immunosuppression of NSCLC via Driving NF-κB Pathway

Researchers explored whether methyltransferase like 3 (METTL3) in cancer associated fibroblasts (CAFs) affects the secretion of IL-18, which drove NSCLC cells to regulate PD-L1-mediated immunosuppression via the nuclear factor kappa B (NF-κB) pathway.