Agonists and Hydrogen Peroxide Mediate Hyperoxidation of β2-Adrenergic Receptor in Airway Epithelial Cells: Implications for Tachyphylaxis to β2-Agonists in Constrictive Airway Disorders

Using airway epithelial cell lines and primary small airway epithelial cells from healthy and asthma-diseased donors, investigators showed that β2AR agonism generated H2O2 in a receptor and NAPDH oxidase-dependent manner.