Human Cerebrospinal Fluid Affects Chemoradiotherapy Sensitivities in Tumor Cells from Patients with Glioblastoma

Investigators examined the effect of human cerebrospinal fluid (CSF) on glioblastoma (GBM) tumors from 25 patients. They found that CSF induces tumor cell plasticity and resistance to standard GBM treatments, temozolomide and irradiation.