NewslettersImmune Regulation NewsIkaros Is a Principal Regulator of Aire+ mTEC Homeostasis, Thymic Mimetic Cell Diversity, and Central ToleranceBy Laurisa Dohm - October 30, 20230150Thymic epithelial cell (TEC)-specific deletion of Ikzf1 in mice resulted in a profound decrease in Aire+ medullary TECs, a global loss of tissue-specific antigengene expression, and the development of autoimmunity.[Science Immunology]Abstract