Cerebral Organoids Derived from Patients with Alzheimer’s Disease with PSEN1/2 Mutations Have Defective Tissue Patterning and Altered Development

Scientists demonstrated that cerebral organoids derived from three Alzheimer’s disease (AD)-iPSC lines with PSEN1(A246E) or PSEN2(N141I) mutations developed the AD-specific markers in vitro, yet they also uncover tissue patterning defects and altered development.