HDL Inhibits Pancreatic Acinar Cell NLRP3 Inflammasome Activation and Protect Against Acinar Cell Pyroptosis in Acute Pancreatitis

Researchers investigated the role of high-density lipoprotein (HDL) in pancreatic necrosis in acute pancreatitis (AP). The roles of healthy human-derived HDL and apoA-I mimic peptide D4F were demonstrated in AP models in vivo and in vitro.