Synergistic Roles of DYRK1A and GATA1 in Trisomy 21 Megakaryopoiesis

To determine how DYRK1A influenced hematopoiesis in concert with GATA1s, investigators used gene editing to disrupt all three alleles of DYRK1A in isogenic T21 induced pluripotent stem cells with and without the GATA1s mutation.