Progress in the Understanding of Estrogen Receptor Alpha Signaling in Triple-Negative Breast Cancer: Reactivation of Silenced ER-α and Signaling through ER-α36

The reactivation of estrogen receptor alpha (ER-α), presents a potential strategy to re-sensitize TNBC to hormonal therapy. Scientists provide up-to-date information related to the direct involvement of miRNA in regulating the translation of ER-α mRNA.