B Cell Mediated CD4 T Cell Co-Stimulation via CD86 Exacerbates Pro-Inflammatory Cytokine Production During Autoimmune Intestinal Inflammation

Depleting B cells through anti-CD20 antibody treatment or blocking co-stimulatory signals mediated by CD86 through CTLA-4-Ig diminished intestinal inflammation in a mouse model of chronic inflammatory-bowel disease at the onset of disease.