Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Anti-Tumor Activity of CD8⁺ T Cells

Scientists performed spatial transcriptomic analysis of head and neck squamous cell carcinoma (HNSCC) specimens with differing immune infiltration and single-cell RNA sequencing of five pairs of tumor and adjacent tissues.