The OX40-TRAF6 Axis Promotes CTLA-4 Degradation to Augment Antitumor CD8⁺ T-cell Immunity

By using TNF receptor-associated factor 6 (TRAF6)-deficient mice and retroviral overexpression experiments, researchers demonstrated that TRAF6 promoted cytotoxic T-lymphocyte associated protein 4 (CTLA-4) degradation in a T-cell-intrinsic manner, which was dependent on the RING domain of TRAF6.