PLGA Nanoparticles Engineering Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Ameliorates Polyethylene Particles Induced Periprosthetic Osteolysis

Scientists demonstrated that human UCMSCs-Exos-encapsulated poly lactic-co-glycolic acid nanoparticles stimulated osteogenic differentiation while inhibiting the generation of reactive oxygen species and subsequent osteoclast differentiation in vitro.