Tumor Cell-Induced Macrophage Senescence Plays a Pivotal Role in Tumor Initiation Followed by Stable Growth in Immunocompetent Condition

Researchers identified one of the requirements for tumor-initiating cells in immunocompetent animals. In addition, they have showed that tumor growth could be inhibited by externally administered nicotinamide mononucleotide against macrophage senescence-like state.