Transcription Factor NFYa Controls Cardiomyocyte Metabolism and Proliferation during Mouse Fetal Heart Development

Researchers studied the role of the transcription factor NFYa in developing mouse hearts. Loss of NFYa altered cardiomyocyte composition, causing a decrease in immature regenerative cells and an increase in trabecular and mature cardiomyocytes, as identified by spatial and single-cell transcriptome analyses.