Targeting the αVβ3/NgR2 Pathway in Neuroendocrine Prostate Cancer

Using in vitro functional assays, researchers demonstrated that NgR2 was crucial in promoting cell adhesion to αVβ3 ligands. They described for the first time co-fractionation of αVβ3 integrin and NgR2 in small extracellular vesicles derived from metastatic prostate cancer patients’ plasma.