MKL/SRF and Bcl6 Mutual Transcriptional Repression Safeguards the Fate and Positioning of Neocortical Progenitor Cells Mediated by RhoA

Using in vivo functional approaches combined with molecular mechanistic analysis, scientists identified a reciprocal regulatory loop between B cell lymphoma 6 (Bcl6) and the RhoA-regulated transcriptional complex megakaryoblastic leukemia/serum response factor (MKL/SRF).