Abundant Binary Promoter Switches in Lineage-Determining Transcription Factors Indicate a Digital Component of Cell Fate Determination

Differentiation of CD34+ hematopoietic progenitors in vitro showed that cells with GATA1 antisense transcription had enhanced GATA2 transcription and a mast cell phenotype, whereas cells with GATA2 antisense transcription had increased GATA1 transcripts and an erythroblast phenotype.