Identification of a Targetable JAK-STAT Enriched Androgen Receptor and Androgen Receptor Splice Variant Positive Triple-Negative Breast Cancer Subtype

Scientists showed that a cohort of TNBC not only expressed androgen receptor (AR) at a much higher rate (∼80%) but also expressesd AR splice variants (∼20%), further subclassifying luminal AR-TNBC.