TRIM3 Facilitates Ferroptosis in Non-Small Cell Lung Cancer through Promoting SLC7A11/xCT K11-Linked Ubiquitination and Degradation

Forced expression of TRIM3 promoted cell death by enhancing the cellular level of ROS and lipid peroxidation. An in vivo study determined that TRIM3 overexpression diminished the tumorigenicity of NSCLC cells, indicating that TRIM3 functioned as a tumor suppressor in NSCLC.