The BRD4-SRPK2-SRSF2 Signal Modulates the Splicing Efficiency of ACSL3 Pre-mRNA and Influences Erastin-Induced Ferroptosis in Osteosarcoma Cells

Mechanically, bromodomain-containing protein 4 (BRD4) controlled the splicing efficiency of the RNA precursor of acyl-CoA synthase 3 (ACSL3) by recruiting serinerich/threonine protein kinase 2 (SRPK2) to assemble the splicing catalytic platform.