Suppression of the KRAS-NRF2 Axis Shifts Arginine into the Phosphocreatine Energy System in Pancreatic Cancer Cells

Unbiased transcriptome and metabolome analyses showed that PDAC cells with disrupted KRASG12D-NRF2 signalling (NRF2−/− cells) shift from aerobic glycolysis to metabolic pathways fed by amino acids.