The C-type Lectin COLEC10 Is Predominantly Produced by Hepatic Stellate Cells and Involved in the Pathogenesis of Liver Fibrosis

Investigators found the C-type lectins including Colec10 and Colec11 were not produced by hepatocytes but predominantly produced by hepatic stellate cells, especially quiescent ones in the mice livers. In vitro overexpression of COLEC10 in LX-2 cells promotes the mRNA expression of extracellular matrix components including COL1A1, COL1A2 and COL3A1 and the extracellular matrix degradation enzyme MMP2.