Preventive Effects of Ramelteon on Bleomycin-Induced Pulmonary Fibrosis in Mice

Ramelteon partially abrogated TGF-β1-induced pulmonary fibrosis and reduced fibroblast proliferation, extracellular matrix deposition, and differentiation into myofibroblasts. In vivo experiments, ramelteon attenuated bleomycin-induced pulmonary fibrosis and collagen deposition.