ROBO1 Deficiency Impairs HSPC Homeostasis and Erythropoiesis via CDC42 and Predicts Poor Prognosis in MDS

Robo1 deficiency impaired HSPC homeostasis and disrupted HSPC pool, especially the reduction of megakaryocyte erythroid progenitors, which caused a blockage in the early stages of erythropoiesis in mice.