CTRP4/Interleukin-6 Receptor Signaling Ameliorates Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation

Researchers demonstrated that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in C1q/TNF related protein 4 (CTRP4)-/- mice compared to WT mice due to increased Th17 cell infiltration.