Inhibition of ACLY Overcomes Cancer Immunotherapy Resistance via Polyunsaturated Fatty Acids Peroxidation and cGAS-STING Activation

Scientists showed that adenosine 5′-triphosphate citrate lyase (ACLY) inhibition up-regulated programmed death ligand 1 immune checkpoint expression in cancer cells and induced T cell dysfunction to drive immunosuppression and compromise its antitumor effect in immunocompetent mice.