Spatially Segregated Defects and IGF1-Responsiveness of Hilar and Peripheral Biliary Organoids from a Model of Alagille Syndrome

Hilar and peripheral Jag1Ndr/Ndr intrahepatic cholangiocyte organoids exhibited differences in Notch signaling status, proliferation, and cholangiocyte commitment which may result in cholangiocyte-to-hepatocyte transdifferentiation.