Programmed Cell Death 11 Modulates but Not Entirely Relies on p53-HDM2 Loop to Facilitate G2/M Transition in Colorectal Cancer Cells

Downregulation of programmed cell death 11 (PDCD11) greatly reduced cancer cell growth in vitro and in vivo, additionally sensitized cells to DNA damage signals, highlighting that PDCD11 was a crucial driving factor of colorectal cancerand a potential target for cancer treatment.