(R, S)-Equol 7-β-D-Glucuronide, but Not Other Circulating Isoflavone Metabolites, Modulates Migration and Tubulogenesis in Human Aortic Endothelial Cells Targeting the VEGF Pathway

Researchers assessed the anti-angiogenic activities of the main circulating isoflavone metabolites and compared them with their corresponding free forms at physiological concentrations. The effects of the conjugated vs. free forms on tubulogenesis, cell migration, and VEGF-induced signaling were investigated in primary human aortic endothelial cells.