Transient Receptor Potential Melastatin 2 Is Involved in Trinitrobenzene Sulfonic Acid-Induced Acute and Chronic Colitis-Associated Fibrosis Progression in Mice

Scientists investigated the role of transient receptor potential melastatin 2 (TRPM2) in acute colitis and chronic colitis-associated fibrosis progression. Acute colitis and chronic colitis-associated fibrosis were induced in TRPM2-deficient and wild-type mice through single and repeated intrarectal injections of 2,4,6-trinitrobenzene sulfonic acid