Butyrate Reduces Adherent-Invasive E. coli-Evoked Disruption of Epithelial Mitochondrial Morphology and Barrier Function: Involvement of Free Fatty Acid Receptor 3

Scientists hypothesized that butyrate would limit the epithelial mitochondrial disruption caused by E. coli-LF82. Human colonic organoids and the T84 epithelial cell line infected with E. coli-LF82 showed a significant increase in mitochondrial network fission that was reduced by butyrate co-treatment.