RAAS-Deficient Organoids Indicate Delayed Angiogenesis as a Possible Cause for Autosomal Recessive Renal Tubular Dysgenesis

To uncover the pathomechanism of Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD), differentiation of ACE-/- and AGTR1-/- iPSCs and AR-RTD patient-derived iPSCs into kidney organoids were leveraged.