KRAS Allelic Imbalance Drives Tumor Initiation Yet Suppresses Metastasis in Colorectal Cancer In Vivo

Researchers reported an in vivo murine model of colorectal cancer featuring deletion of wild-type Kras in the context of oncogenic Kras. Deletion of wild-type Kras exacerbates oncogenic KRAS signaling through MAPK and thus drives tumor initiation.