Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsNewsletters
A Thiol-Rich Immunomodulatory Injectable Hydrogel Suppresses Endometrial Fibrosis to Restore Fertilization
Researchers reported a thiol-rich immunomodulatory injectable hydrogel (TR-gel) that forms in situ through Michael addition between acrylated hyaluronic acid and thiolated hyaluronic acid. In...
Damon Runyon Cancer Research Foundation Awards $4.2 Million to Exceptional Early-Career Scientists
The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the...
FibroBiologics Granted US Patent Covering the Use of Fibroblasts to Enhance Survival and Function of Transplanted Insulin-Producing Islets
FibroBiologics, Inc. announced that the United States Patent and Trademark Office has issued a patent that describes methods utilizing fibroblasts to improve the engraftment...
Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy
To support human islet viability and function, researchers developed alginate-based bioinks incorporating human pancreatic decellularized ECM.
A Practical Toolbox for Modelling Fibrosis In Vitro
The authors define the hallmarks of fibrosis across organ systems to establish foundational design criteria necessary for modelling human fibrosis in vitro.
A Low-Crosslinking Hydrogel Integrating Prodrug Nanoparticles Modulates Neuroinflammation and ECM Deposition for Enhanced Spinal Cord Regeneration
Scientists explored a localized biomaterial delivery strategy via regulating the crosslinking degree of hydrogel matrix, in which high-crosslinking density of hydrogel tends to exacerbate...
Experience-Dependent Modulation of Extracellular Matrix Integrity Supports Perceptual Skill Learning and Memory
Investigators tracked and manipulated auditory cortical ECM integrity in Mongolian gerbils during perceptual learning. They found that the ECM undergoes rapid training-induced changes, degrading...
CD177 Neutrophils Drive Extracellular Matrix Remodelling and HGF-Alpha Release in ALPPS-Induced Liver Regeneration
Researchers combined single-cell RNA sequencing and spatial transcriptomics to comprehensively profile immune microenvironment changes in the remnant liver during associating liver partition and portal...
Histone Lactylation in Cancer-Associated Fibroblasts Induces Extracellular Matrix Remodeling and Immunosuppression to Promote Colorectal Cancer Progression
The authors demonstrated that elevated lactate levels in CAFs reprogram the epigenetic landscape to promote tumor progression and immunosuppression, highlighting the potential of targeting...
Unlocking Myofibroblast Plasticity to Reverse Salivary Gland Fibrosis
Scientists examine current mechanistic evidence undergirding myofibroblast activation, survival, and its phenotypic reversal, focusing on restoring glandular function.
A Novel CAF Population Coordinates Hyper-Suppressive Regulatory T Cell Recruitment and Localization in Lung Cancer
Researchers identified a population of immunomodulatory cancer-associated fibroblasts (CAFs) that play a pivotal role in shaping the lung tumor microenvironment by driving the recruitment...
TIF1γ Regulates Stability of Regulatory T Cells during Inflammation
Scientists showed that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge.
