YAP and TAZ Couple Osteoblast Precursor Mobilization to Angiogenesis and Mechanoregulation in Murine Bone Development

Researchers showed that the mechanoresponsive transcriptional regulators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) spatially couple osteoblast precursor mobilization to angiogenesis, regulated vascular morphogenesis to control cartilage remodeling and mediate mechanoregulation of embryonic murine osteogenesis.