Multiomics Analysis of Cultured Mouse Periodontal Ligament Cell-Derived Extracellular Matrix

Researchers systematically analyzed cultured mouse periodontal ligament cell (PDLC)-derived ECM and compared it to mouse PDL tissue as a reference. Proteomic analysis revealed that, compared to PDL tissue, the cultured PDLC-derived ECM had a lower proportion of fibrillar collagens with increased levels of glycoprotein, corresponding to an immature ECM status.