EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer

Inhibition of an epidermal growth factor receptor/Erb-B2 receptor (EGFR/ERBB2)-signaling network in pancreatic ductal adenocarcinoma organoid-derived cultures and mouse models differentially impacted distinct cancer-associated fibroblasts subtypes, providing insights into mechanisms underpinning their heterogeneity.