Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo

Single-cell analysis revealed that a myriad of metabolic changes occurred during cystogenesis, including defective autophagy. Experimental activation of autophagy via ATG5 overexpression or primary cilia ablation significantly inhibited cystogenesis in olycystic kidney disease kidney organoids.