Stabilization of Pin1 by USP34 Promotes Ubc9 Isomerization and Protein Sumoylation in Glioma Stem Cells

Scientists demonstrated that peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) was deubiquitinated and stabilized by USP34, which promoted isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support glioma stem cell maintenance.