The Paracaspase MALT1 Controls Cholesterol Homeostasis in Glioblastoma Stem-Like Cells through Lysosome Proteome Shaping

By combining RNA sequencing with proteome-wide label-free quantification, investigators reported that MALT1 repression in patient-derived glioblastoma stem-like cells altered the homeostasis of cholesterol, which accumulated in late endosomes-lysosomes.