JOSD2 Mediates Isoprenaline-Induced Heart Failure by Deubiquitinating CaMKIIδ in Cardiomyocytes

The authors demonstrated that deficiency of a deubiquitinase, Josephin domain-containing protein 2 (JOSD2), ameliorated isoprenaline- and myocardial infarction-induced cardiac hypertrophy, fibrosis, and dysfunction both in vitro and in vivo.