GCF2 Mediates Nicotine-Induced Cancer Stemness and Progression in Hepatocellular Carcinoma

The authors reported that nicotine enhanced hepatocellular carcinoma cancer stemness and malignant progression by upregulating the expression of GC-rich binding factor 2 (GCF2) and subsequently activating the Wnt/ꞵ-catenin/SOX2 signaling pathway.