Cell Membrane-Anchored and Tumor-Targeted IL-12 T-Cell Therapy Destroys Cancer-Associated Fibroblasts and Disrupts Extracellular Matrix in Heterogenous Osteosarcoma Xenograft Models

Investigators used RNA sequencing to assess whether the recently invented membrane-anchored and tumor-targeted IL-12-armed T cells, which bind cell-surface vimentin on tumor cells, could destroy cancer-associated fibroblasts to disrupt the extracellular matrix.