RNA-Binding Protein RBM5 Plays an Essential Role in Acute Myeloid Leukemia by Activating the Oncogenic Protein HOXA9

Investigators performed genome-wide CRISPR/Cas9 screening in the HOXA9-driven reporter acute leukemia cells. They identified a poorly characterized RNA-binding protein, RBM5, as the top candidate gene required to maintain leukemia cell fitness.