Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin

Researchers obtained skin fibroblasts from members of amyotrophic lateral sclerosis and frontotemporal dementia family. They reprogrammed these fibroblasts to induced pluripotent stem cells (iPSCs) and generated cortical organoids as well as induced stage-wise differentiation of the iPSCs to neurons.