ZBP1 Activation Triggers Hematopoietic Stem and Progenitor Cell Death Resulting in Bone Marrow Failure in Mice

Scientists demonstrated that similar to a RIPK3 deficiency, an MLKL deficiency significantly extended survival and like Ripk3 deficiency partially restored hematopoiesis in Ripk1HEM KO mice revealing that both necroptosis and apoptosis contribute to bone marrow failure in these mice.