Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization

In a transient middle cerebral artery occlusion (MCAO) mouse model of an ischemic stroke, researchers demonstrated that intravenously injected mIL-10@MLNPs induce IL-10 production and enhance the M2 polarization of microglia.