A Gut Microbiota-Bile Acid Axis Promotes Intestinal Homeostasis Upon Aspirin-Mediated Damage

Mice supplemented with P. goldsteiniior its bile acid metabolite, 7-keto-lithocholic acid (7-keto-LCA), showed reduced aspirin-mediated damage of the intestinal niche and gut barrier, effects that were lost with a P. goldsteinii hdhA mutant unable to generate 7-keto-LCA.