Membranal Expression of Calreticulin Induced by Unfolded Protein Response in Melanocytes: A Mechanism Underlying Oxidative Stress-induced Autoimmunity in Vitiligo

Investigators found that the protein kinase RNA-like ER kinase branch of unfolded protein response was confirmed to be responsible for the overexpression and membranal translocation of calreticulin in melanocytes under oxidative stress.