Altered Histone Acetylation Patterns in Pancreatic Cancer Cell Lines Induce Subtype-Specific Transcriptomic and Phenotypical Changes

Researchers determined if drug‑induced epigenetic reprogramming of pancreatic cancer cells affects PDAC subtype identity and chemosensitivity. Classical and basal‑like PDAC cell lines PaTu‑S, Capan‑1, Capan‑2, Colo357, PaTu‑T, PANC‑1, and MIAPaCa‑2, were treated for a short and long period with histone acetyltransferase and histone deacetylase inhibitors.